FORMULATION GUIDE: CBDC-75Use our TOTALLY FREE formulations below as a guide to quickly get you started in creating your own, custom formulated oral solid dosage forms using our 75% CBD Directly Compressible Powder (CBDC-75).
| INGREDIENTS | mg/Tablet | |
| 1 | CBDC-75 | 50 |
| 2 | Lactose | 346.08 |
| 3 | Hydroxypropylmethylcellulose 2208 | 66 |
| 4 | Magnesium stearate | 2.85 |
| 5 | Colloidal anhydrous silica | 5.7 |
| 6 | Talc | 28.6 |
Directions:
1. Mix all ingredients except 4 for 10 minutes.
2. Add Magnesium Stearate and mix for 1 minute.
3. Compress using low compression forces.
| INGREDIENTS | mg/Tablet | |
| 1 | CBDC-75 | 22 |
| 2 | Sorbitol (crystalline) | 150 |
| 3 | Kollidon R® VA 64 | 5 |
| 4 | Menthol (crystalline) | 5 |
| 5 | Eucalyptol (crystalline) | 5 |
| 6 | Aspartame, potassium | 1 |
| 7 | Saccharin sodium | 0.1 |
| 8 | Aerosil R® 200 | 2 |
| 9 | Magnesium stearate | 1 |
Directions:
1. Mix all components, pass through an 0.8-mm sieve.
2. Compress into lozenge, using 8-mm biplanar punches.
| INGREDIENTS | mg/Tablet | |
| 1 | CBDC-75 | 50 |
| 3 | Dextrose | 400 |
| 4 | PVP 90 | 4 |
| 5 | PEG-6000 (powder) | 6 |
Directions: Pass all ingredients through a 0.8-mm sieve and press with high-compression force.
| INGREDIENTS | mg/Tablet | |
| 1 | CBDC-75 | 5 |
| 2 | Sorbitol (crystallized) | 150 |
| 3 | Menthol (crystalline) | 4 |
| 4 | Eucalyptol (crystalline) | 4 |
| 5 | Aspartame, potassium | 1 |
| 6 | Saccharine sodium | 0.1 |
| 7 | Aerosil 200 | 1 |
| 8 | Magnesium stearate | 1 |
Directions:
1. Mix all components, pass through an 0.8-mm sieve, and press with medium-compression force.
| INGREDIENTS | mg/Tablet | |
| 1 | CBDC-75 | 24 |
| 2 | Sodium bicarbonate | 27 |
| 3 | Citric acid anhydrous | 27 |
| 4 | Microcrystalline cellulose | 10 |
| 5 | Xylitol | 10 |
| 6 | Sucrose stearate | 2 |
Directions:
1. All of the ingredients are dried at 40.C to 60C to significantly reduce the moisture content of the material.
2. Mix and compress at low forces.
| INGREDIENTS | mg/Tablet | |
| 1 | CBDC-75 | 10 |
| 2 | Sodium bicarbonate | 198 |
| 3 | Citric acid | 100 |
Directions:
1. The components (i.e., CBDC-75, sodium bicarbonate, and citric acid are thoroughly mixed.
2. An effervescent tablet is produced by placing the mixture in a die, following with compression with an appropri-ate punch. Relatively little compression force is used (e.g., about 3000 to about 20000 pounds of force).
| INGREDIENTS | mg/Tabet | |
| 1 | CBDC-75 | 20 |
| 2 | Sorbitol crystalline | 10.4 |
| 3 | Tartaric acid powder | 14.3 |
| 4 | Sodium carbonate | 18.7 |
| 5 | PVP K25 | 1.7 |
| 6 | PEG 6000 powder | 1.1 |
Directions;
1. Mix all components and pass through a 0.5-mm sieve.
2. Press to tablets at 66 mg.
| INGREDIENTS | mg/Tablet | |
| 1 | CBDC-75 | 13 |
| 2 | Citric acid anhydrous | 650 |
| 3 | Sodium bicarbonate granular | 367 |
| 4 | Sodium carbonate anhydrous | 40 |
| 5 | Flavor | 25 |
| 6 | Color | 5 |
| 7 | Sodium benzoate | 7.5 |
| 8 | Water, purified | 2 |
Directions 1. Premix the CBDC-75 granule with sodium bicarbonate and Sodium Benzoate. Mix the color with sodium carbonate. Place citric acid in a bowl of a suitable blender.
2. Slowly add 2 mg of water to the citric acid and mix thoroughly to form a moist blend. Add to the blend, in sequence, while mixing, the sodium bicarbonate mix and the sodium carbonate color mix. Mix until uniformly dis-tributed.
3. Compress tablets using suitably sized tooling. Cure the tablets, cool, and package in aluminum foil.
| INGREDIENTS | mg/Tablet | |
| 1 | CBDC-75 | 112 |
| 2 | Sorbitol (instant) | 200 |
| 3 | Anhydrous citric acid | 1000 |
| 4 | Sodium bicarbonate | 587 |
| 5 | PEG-6000 (powder) | 65 |
| 6 | Lemon flavor | 10 |
| 7 | Cyclamate sodium | 25 |
| 8 | Saccharin sodium | 1 |
Directions:
1. Dry the sodium bicarbonate for 1 hour at 100.C, mix with the other components, pass all through a 0.8-mm sieve,
| INGREDIENTS | mg/Tablet | |
| 1 | CBDC-75 | 10 |
| 2 | Tartaric acid (fine crystals) | 36 |
| 3 | Sodium bicarbonate | 44 |
| 5 | Saccharin sodium | 20 |
| 6 | Sodium chloride (milled) | 2 |
| 7 | Lime flavor | 0.5 |
| 8 | Sugar (fine crystals) | 170 |
Directions:
- Mix items 1-8 in a V-blender and mix for 15 minutes.
- Compress at low forces.
| INGREDIENTS | mg/Tablet | |
| 1 | CBDC-75 | 31 |
| 2 | Sodium bicarbonate/tartaric acid (powder) | 45 |
| 3 | PVP K30 | 60 |
| 6 | Sucrose (crystalline) | 40 |
| 8 | Crospovidone | 20 |
| 9 | PEG-6000 (powder) | 6 |
Directions: Mix all ingredients for 15 minutes and compress al high forces.
| INGREDIENTS | mg/Tablet | |
| 1 | CBDC-75 | 20 |
| 2 | Lactose Granular | 133 |
| 3 | Microcrystalline cellulose 102 | 40 |
| 4 | Povidone | 24 |
| 5 | Fruit Punch Flavor | 2 |
| 6 | Magnesium stearate | 2 |
Directions:
1. Mix all components except Magnesium stearate and blend in a V-blender for 10 minutes.
2. Add Magnesium stearate and mix an additional 1 minute and compress.
| INGREDIENTS | mg/Tablet | |
| 1 | CBDC-75 | 5 |
| 2 | Mannitol DC Grade | 92.97 |
| 3 | Gelatin | 0.5 |
| 4 | Aspartame | 0.5 |
| 5 | Colloidal silicon Dioxide | 1 |
Directions:
1. Pass item 2 through 0.7-mm sieve and collect in a stainless steel container.
2. Charge half quantity of step 1 in a tumbler.
3. Pass items 1 and items 3 to 5 through 0.5-mm sieve and collect in a container.
4. Add 15% Mannitol from step 1 to step 3 and mix well.
5. Compress at medium force.
| INGREDIENTS | mg/Tablet | |
| 1 | CBDC-75 | 100 |
| 2 | Ascorbic acid | 250 |
| 3 | Lactose DC Powder | 100 |
| 4 | Crospovidone | 20 |
| 5 | Macrogol 6000 powder | 3 |
Directions: Pass all components through a 0.8-mm sieve, mix, and press with medium-compression force.
| INGREDIENTS | mg/Tablet | |
| 1 | CBDC-75 | 10 |
| 2 | Pharmaburst | 180.6 |
| 3 | Acesulfame K | 2.7 |
| 4 | Magnesium stearate | 2 |
| 5 | Talc (fine powder) | 2 |
| 6 | Dry mint flavor | 2.7 |
Directions:
1. Sift and mix items 1, 2, 3, and 6.
2. Lubricate with magnesium stearate and fine talc powder.
3. Compress into 200-mg tablets, using 6-mm punches.
| INGREDIENTS | mg/Tablet | |
| 1 | CBDC-75 | 16 |
| 2 | Microcrystalline cellulose 101 | 50 |
| 3 | Veegum F | 10 |
| 4 | Sodium starch glucolate 42.00 | 8 |
| 5 | Magnesium stearate | 2 |
Directions:
1. Pass items 1 to 4 through a 250 mesh screen and blend for 10 minutes.
2. Add item 5, blend for 1 minute, and pass the mixture through a #11 sieve.
3. Compression at low compression force.
| INGREDIENTS | mg/Tablet | |
| 1 | CBDC-75 | 8 |
| 2 | Lactose Granular | 24 |
| 3 | Microcrystalline cellulose 101 | 40 |
| 4 | Povidone | 24 |
| 5 | Sodium starch glycolate | 22 |
| 6 | Magnesium stearate | 2 |
Directions:
1. Mix all components except Magnesium stearate and blend in a V-blender for 10 minutes.
2. Add Magnesium stearate and mix an additional 1 minute and compress.
| INGREDIENTS | mg/Tablet | |
| 1 | CBDC-75 | 12 |
| 2 | Magnesium trisilicate | 25 |
| 3 | Lactose Mono DC Grade | 23 |
| 4 | Aerosil R® 200 | 1 |
| 5 | Magnesium stearate | 1 |
| 6 | Cyclamate sodium | 1.2 |
| 7 | Menthol | 2 |
Directions:
1. Mix all components, pass through an 0.8-mm sieve, and press with a compression force of 20 kN.
| INGREDIENTS | mg/Tablet | |
| 1 | CBDC-75 | 100 |
| 2 | Dextrose | 500 |
| 3 | PVP 90 | 4 |
| 4 | Water | QS |
| 5 | PEG-6000 (powder) | 16 |
Directions:
1. Granulate mixture of items 1 and 2 with solution of items 4 and 5 (in a fluidized bed), sieve, add item 6, and press with high-compression force.
2. Compress into 620-mg tablets, using 12-mm biplanar punches.
| INGREDIENTS | mg/Tablet | |
| 1 | CBDC-75 | 50 |
| 2 | Sorbitol (granular) | 85 |
| 3 | Lactose (120 mesh) | 10 |
| 4 | FD&C Yellow Dye No. 5 lake | 3.3 |
| 5 | MCC 101 | 82.9 |
| 6 | Silica gel | 11.6 |
| 7 | Lemon Flavor | 8.29 |
| 8 | Strawberry Flavor | 0.5 |
| 9 | Sodium cyclamate | 8.29 |
| 10 | Magnesium stearate | 33.2 |
Directions:
1. Pass CBDC-75 granulate, sodium ascorbate, sorbitol, lactose, FD&C Yellow Dye, microcrystalline cellulose, silica gel, flavors, and sodium cyclamate through a 420-mircrogram screen.
2. Using a comminuting mill, pass the coarse granules through a 420-microgm screen (knives forward, medium speed).
3. Transfer milled materials to a suitable blender, and blend for 5 minutes.
4. Screen the magnesium stearate by hand through an 840-microgm screen, and transfer to blender.
5. Mix for 1 minute.
6. Compress using 18-mm standard concave punches.
| INGREDIENTS | mg/Tablet | |
| 1 | CBDC-75 | 30 |
| 2 | Sorbitol (crystalline) | 150 |
| 3 | MCC 101 | 140 |
| 4 | Crospovidone | 30 |
| 5 | PEG-6000 (powder) | 50 |
| 6 | Orange Flavor | 1 |
Directions:
1. Pass all components through an 0.8-mm sieve, mix, and press with low-compression force.
2. Compress using 12-mm biplanar punches.
3. Crospovidone may be omitted and the tablet weight adjusted.
| INGREDIENTS | mg/Tablet | |
| 1 | CBDC-75 | 90 |
| 2 | Mannitol granular | 246 |
| 3 | Microcrystalline cellulose | 30 |
| 4 | Aspartame | 9 |
| 5 | Dyes | 1 |
| 6 | Citric acid | 2 |
| 7 | Flavor | 2 |
| 8 | Magnesium stearate | 4 |
Directions:
1. The CBDC-75 Granulate is coated with a layer of a taste-masking composition with a thickness of about 3 to 10 micrograms. The coating should be substantially free of cracks, holes, and other imperfections when examined under a scanning electron microscope at 100 to 500 magnification.
2. Charge items 1 to 7 in a suitable blender and mix for 20 minutes.
3. Add item 8 to step 2 and blend for 2 minutes.
4. Compress the appropriate quantity.
| INGREDIENTS | mg/Tablet | |
| 1 | CBDC-75 | 30 |
| 2 | Sucrose, milled | 60 |
| 3 | Crospovidone XL | 55 |
| 4 | Orange flavor | 3 |
| 5 | Strawberry flavor | 3 |
| 6 | MCC 102 | 155 |
| 7 | Magnesium Stearate | 1 |
Directions:
1. Mix all items for 15 minutes, pass through a sieve, add Magnesium Stearate and mix for an additional 1 minute. Press with medium compression force.
| Ingredients | mg/tablet | |
| 1 | CBDC-75 | 30 |
| 2 | DC Grade Lactose | 100 |
| 3 | Magnesium stearate | 2 |
Directions:
1. Discharge all the ingredients through a 0.5-mm sieve, and mix for 10 minutes.
2. Press into 132-mg CBD tablets using medium-compression force and 8-mm biplanar punches.
| INGREDIENTS | mg/Tablet | |
| 1 | CBDC-75 | 20 |
| 2 | Starch 1500 | 375 |
| 3 | MCC 102 | 328.1 |
| 4 | Stearic acid | 14.8 |
| 5 | Fumed silica | 5.55 |
| 6 | Magnesium stearate | 1.85 |
Directions
1. Blend half of the Starch 1500 with the fumed silica and CBD Granulate for 5 minutes.
2. Pass this mixture through a 40-mesh screen and return to blender.
3. Add the remaining starch 1500 to the material in step 1 and blend for 5 additional minutes.
4. Add the microcrystalline cellulose (MCC 102) and stearic acid to the material from step 2 and blend for an additional 10 minutes.
5. Add the magnesium stearate to the material from step 3 and blend for an additional 5 minutes.
| INGREDIENTS | mg/Tablet | |
| 1 | CBDC-75 | 100 |
| 2 | Starch 1500 | 25.52 |
| 3 | Prosolv 50 | 21.33 |
| 4 | Sodium Starch Glycolate | 6.33 |
Directions:
1. Blend all ingredients in a twin-shell blender for 10 minutes.
2. Compress into 153 mg tablets.
| INGREDIENTS | mg/Tabet | |
| 1 | CBDC-75 | 13.1 |
| 2 | Lactose anhydrous | 220.9 |
| 3 | Microcrystalline cellulose | 160 |
| 4 | Magnesium stearate | 2 |
| 5 | Croscarmellose sodium type A | 4 |
Directions:
1. Pre-mix CBDC-75 with one-third quantity of the microcrystalline cellulose and one-half the quantity of the anhydrous lactose in a blender for 5 minutes at 20 rpm.
2. To the premix is added the remaining two-thirds of the microcrystalline cellulose and the remaining one-half of the anhydrous lactose. Blend for 10 minutes at 20 rpm.
3. Add croscarmellose sodium to the blended powders in step 2 and mix for 5 minutes at 20 rpm.
4. Add item 4 to the mixture after passing it through a 90-mesh screen and blend for an additional 5 minutes at 20 rpm.
5. Compress into 400 mg tablets, using a suitable punch.
| INGREDIENTS | mg/Tablet | |
| 1 | CBDC-75 | 40 |
| 2 | Lactose anhydrous | 312 |
| 3 | Microcrystalline cellulose 102 | 240 |
| 4 | Sodium carboxymethylcellulose | 6 |
| 5 | Magnesium stearate | 3 |
Directions:
CBDC-75 is first blended with one-third of microcrystalline cellulose 102 and with one-half of anhydrous lactose. The premixture obtained is then blended with both remaining excipients and it is mixed again. Sodium salt of carmellose is added under mixing to be followed with magnesium stearate to finish the mixture blending. When homogenized by forth mixing the mixture is subjected to the compression.
| INGREDIENTS | mg/Tablet | |
| 1 | CBDC-75 | 13 |
| 2 | Maize starch | 11 |
| 3 | Mannitol | 105 |
| 4 | Magnesium stearate | 1 |
Directions:
A mixture containing CBDC-75, mannitol, maize starch, and microcrystalline cellulose is blended in a container at the stirrer speed of 14 rpm and under the normal temperature and humidity (25.C, 60% R.H.). Magnesium stearate is added to the premixed mixture. After homogenization, the precompression mixture is compressed on a rotary compression machine to form flat (cylindrical) or oval-shaped tablets of 130 mg in the mass.
| INGREDIENTS | mg/Tablet | |
| 1 | CBDC-75 | 50 |
| 2 | Lactose Mono (Graulated) | 200 |
| 3 | Prosolv 50 | 105 |
| 4 | Magnesium stearate | 1 |
Directions:
A mixture containing CBDC-75, Lactose, and Prosolv 50 is blended in a container at the stirrer speed of 14 rpm and under the normal temperature and humidity (25.C, 60% R.H.). Magnesium stearate is added to the premixed mixture. After homogenization, the precompression mixture is compressed on a rotary compression machine to form flat (cylindrical) or oval-shaped tablets of 355mg tablets.
| INGREDIENTS | mg/Tablet | |
| 1 | CBDC-75 | 28 |
| 2 | Ludipress | 225 |
| 3 | Crospovidone | 10 |
| 4 | Magnesium stearate | 10 |
Directions:
1. Mix all components, pass through a 0.5-mm sieve, and press with low compression force.
| INGREDIENTS | mg/Tablet | |
| 1 | CBDC-75 | 45 |
| 2 | Gelatin powder | 175 |
| 3 | Croscarmellose sodium | 3 |
| 4 | Talc | 5 |
| 5 | Magnesium stearate | 3 |
Directions:
1. Add CBDC-75, gelatin, and croscarmellose sodium, one item at a time, in a suitable blender, and mix for 15 minutes. 2. Add talc and magnesium stearate, and mix for an additional 5 minutes. 3. Compress into 230-mg tablets, using 6-mm punches.
| INGREDIENTS | mg/Tablets | |
| 1 | CBDC-75 | 5 |
| 2 | Lactose mono DC | 100 |
| 3 | Magnesium stearate | 2 |
| 4 | Aerosil 200 | 1 |
Directions:
1. Pass all components through an 0.8-mm sieve, mix, and press with very low-compression force (4 kN).
2. Compress into 202-mg tablets, using 8-mm biplanar punches.
3. This is a very low active ingredient formulation (5 mg), if content uniformity is a problem, prepare a premix of the active ingredient with a small part of the lactose monohydrate before mixing with the other components of the formulation.